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- Sacagawea
- Sagan, Carl
- Saint Patrick/Saint Patrick's Day
- Saints (Catholic)
- Salinger, J.D.
- Sampras, Pete
- Samuelson, Paul
- Sandburg, Carl
- Sanger, Margaret
- Santa Claus
- Sapphire
- Sargent, John Singer
- Scalia, Antonin
- Schelling, Thomas
- Schools:
- Schroedinger, Erwin
- Schubert, Franz
- Schumann, Robert
- Scientists & Mathematicians
- Scieszka, Jon
- Scouts (boy)
- Sears, Richard
- Selden, George
- Sendak, Maurice
- Seton, Elizabeth Bayley
- Seurat, Georges
- Seuss, Dr.
- Sexton, Anne
- Shakespeare, William
- Shih Huang Ti
- Shockley, William Bradford
- Shriver, Eunice Kennedy
- Sibelius, Jean
- Sills, Beverly
- Simon, Paul
- Simone, Nina
- Sisley, Alfred
- Skinner, B.F.
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- Slavery
- Sleet, Moneta
- Slocum, Frances
- Small, David
- Smith, Adam
- Smith, Bessie
- Smith, George
- Smith, Lane
- Smith, Margaret Chase
- Smith, Vernon L.
- Smith, Zadie
- Smithies, Oliver
- Smoot, George F.
- Snicket, Lemony (Daniel Handler)
- Socrates
- Soddy, Frederick
- Sondheim, Stephen
- Sotomayor, Sonia
- Spenser, Edmund
- Spielberg, Steven
- Spinoza, Benedict de
- Stalin, Josef
- Stanton, Elizabeth Cady
- Steinbeck, John
- Steinem, Gloria
- Sterling, Dorothy
- Stevens, John Paul
- Stevens, Wallace
- Stevenson, Robert Louis
- Stine, R.L.
- Stockton, Richard
- Stowe, Harriet Beecher
- Stratton-Porter, Gene
- Strauss, Richard
- Stuart, Gilbert
- Sulston, John E.
- Sumner, Charles
- Sutcliff, Rosemary
- Sydenham, Thomas
- Szostak, Jack
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